Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France.
FEBS Lett. 2010 Dec 15;584(24):4845-50. doi: 10.1016/j.febslet.2010.09.001. Epub 2010 Sep 7.
T cell antigen receptor signaling is triggered and controlled in specialized cellular interfaces formed between T cells and antigen-presenting cells named immunological synapses. Both microtubules and actin cytoskeleton rearrange at the immunological synapse in response to T cell receptor triggering, ensuring in turn the accuracy of intracellular signaling. Recent reports show that the cross-talk between the cortical actin cytoskeleton and microtubule networks is key for structuring the immunological synapse and for controlling T cell receptor signaling. Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling.
T 细胞抗原受体信号转导是在 T 细胞与抗原呈递细胞之间形成的专门细胞界面（称为免疫突触）中触发和控制的。微管和肌动蛋白细胞骨架在 T 细胞受体触发后在免疫突触中重新排列，从而确保细胞内信号转导的准确性。最近的报告表明，皮质肌动蛋白细胞骨架和微管网络之间的串扰对于构建免疫突触和控制 T 细胞受体信号转导是关键的。因此，免疫突触的结构以及信号转导机制与各种细胞骨架元件之间的相互作用对于 T 细胞信号转导的精细调节至关重要。
