[精神药物制剂对大鼠大脑皮层中环磷酸腺苷磷酸二酯酶活性的影响]
[Effect of psychotropic preparations on cyclic AMP phosphodiesterase activity in the rat cerebral cortex].
作者信息
Shchekoldina T G, Vatolkina O E, Libinzon R E
出版信息
Vopr Med Khim. 1978 Mar-Apr;24(2):166-9.
PMID:208286
Abstract
Effect of various psychotropic preparations on cAMP phosphodiesterase was studied. Almost all the psychotropic drugs studied were shown to inhibit the enzymatic activity. Neuroleptics--derivatives of phenothiazine and butyrophene--caused the strongest inhibitory effect.
摘要
研究了各种精神药物对环磷酸腺苷磷酸二酯酶的作用。几乎所有所研究的精神药物都显示出抑制酶活性的作用。抗精神病药物——吩噻嗪和丁酰苯的衍生物——产生了最强的抑制作用。
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