银杏双黄酮对大鼠脂肪组织中环磷酸腺苷磷酸二酯酶的抑制作用。
Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue.
作者信息
Saponara R, Bosisio E
机构信息
Institute of Pharmacological Sciences, Faculty of Pharmacy, Via Balzaretti 9, 20133 Milan, Italy.
出版信息
J Nat Prod. 1998 Nov;61(11):1386-7. doi: 10.1021/np970569m.
PMID:9834158
Abstract
This work compares the inhibition of cAMP-phosphodiesterase in rat adipose tissue by a mixture of Ginkgo biloba biflavones with the effect of individual dimeric flavonoids. The degree of enzyme inhibition by G. biloba biflavones was amentoflavone > bilobetin > sequoiaflavone > ginkgetin = isoginkgetin. Sciadopitysin was almost inactive.
摘要
这项研究比较了银杏双黄酮混合物对大鼠脂肪组织中环磷酸腺苷磷酸二酯酶的抑制作用与单个二聚体黄酮类化合物的作用效果。银杏双黄酮对该酶的抑制程度为：穗花杉双黄酮>白果双黄酮>异叶杉双黄酮>银杏黄素=异银杏黄素。日本金松双黄酮几乎没有活性。
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