Therapeutic Immunology Group, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, United Kingdom.
Curr Opin Immunol. 2010 Oct;22(5):560-5. doi: 10.1016/j.coi.2010.08.002. Epub 2010 Sep 7.
Infectious tolerance describes an in vivo process in which tolerance is passed on from one population of lymphocytes to another. In this way, short-term therapy aimed at generating infectious tolerance has the potential to achieve long term, self-perpetuating immune homeostasis in a clinical setting. In recent years, a number of differing strategies have successfully achieved tolerance in vivo. These include harnessing regulatory T cells and tolerogenic antigen presenting cells, promoting tolerogenic interactions or inhibiting activation of effector cells. Many of these are just beginning to face the harsh realities of the therapeutics industry.
感染性耐受描述了一种体内过程，其中耐受性从一群淋巴细胞传递到另一群淋巴细胞。通过这种方式，旨在产生感染性耐受的短期治疗有可能在临床环境中实现长期、自我维持的免疫稳态。近年来，许多不同的策略已成功地在体内实现了耐受。这些策略包括利用调节性 T 细胞和耐受原性抗原呈递细胞、促进耐受原性相互作用或抑制效应细胞的激活。其中许多策略才刚刚开始面对治疗学行业的严酷现实。
