Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham, Cambridge CB223AT, UK.
Trends Immunol. 2010 Oct;31(10):370-6. doi: 10.1016/j.it.2010.07.002. Epub 2010 Sep 9.
The progressive maturation of T cells is accompanied by their migration through the thymus, with each selection stage occurring in distinct microenvironments. Many specialized receptor-ligand pairs have been defined that drive T cell differentiation, but our understanding of the complex relationship between T cells and the thymic stroma is incomplete. Recent reports have identified a role for the chemokine stromal cell-derived factor 1α and its receptor CXC chemokine receptor 4 in β-selection. This review explores these findings in detail.
T 细胞的成熟伴随着它们在胸腺中的迁移，每个选择阶段都发生在不同的微环境中。许多专门的受体-配体对已经被定义，这些对驱动 T 细胞分化，但我们对 T 细胞与胸腺基质之间复杂关系的理解并不完整。最近的报告确定了趋化因子基质细胞衍生因子 1α及其受体 CXC 趋化因子受体 4 在β选择中的作用。这篇综述详细探讨了这些发现。
