Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan,
J Mol Med (Berl). 2014 May;92(5):433-9. doi: 10.1007/s00109-014-1123-8. Epub 2014 Apr 11.
Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and maintenance of hematopoietic stem cells (HSCs), production of immune cells, homing of primordial germ cells (PGCs), cardiogenesis, arterial vessel branching in some organs, and appropriate assemblies of particular types of neurons. This review focuses on the pathophysiological relevance of CXCL12-CXCR4 signaling in mammals.
趋化因子最初因其能够决定白细胞的迁移和激活而被识别。然而，CXC 趋化因子配体 12（CXCL12，也称为基质细胞衍生因子-1）及其受体 CXCR4 是第一个被证明对发育过程至关重要的趋化因子和受体，包括造血干细胞（HSCs）的归巢和维持、免疫细胞的产生、原始生殖细胞（PGCs）的归巢、心脏发生、某些器官中的动脉血管分支以及特定类型神经元的适当组装。本综述重点介绍了 CXCL12-CXCR4 信号在哺乳动物中的病理生理学相关性。
