Department of Neuropsychology, Children's Healthcare of Atlanta, GA, USA.
Arch Clin Neuropsychol. 2010 Dec;25(8):762-70. doi: 10.1093/arclin/acq066. Epub 2010 Sep 8.
Although research on adults with frontal lobe epilepsy (FLE) has increased in recent years, delays in frontal lobe development preclude the generalization of these findings to children. This study compared children with FLE with typically developing children on cognitive and executive tests. Additionally, the differences between children with early and late seizure onset were explored. Results indicated comparable intelligence among all groups; however, the FLE cohort performed worse than controls on executive tests. The age of seizure onset differentially affected executive performance, such that early FLE onset resulted in greater executive dysfunction. The implications of these findings are discussed.
尽管近年来对额叶癫痫（FLE）成人的研究有所增加，但额叶发育迟缓使得这些发现无法推广到儿童。本研究比较了 FLE 患儿和正常发育儿童在认知和执行测试方面的差异。此外，还探讨了早发性和晚发性癫痫发作儿童之间的差异。结果表明，所有组的智力相当；然而，FLE 组在执行测试中的表现逊于对照组。癫痫发作的年龄对执行功能有不同的影响，即早发性 FLE 发作导致更大的执行功能障碍。讨论了这些发现的意义。
