Cornish-Bowden A, Szedlacsek S E
Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique, Marseille, France.
Biomed Biochim Acta. 1990;49(8-9):829-37.
Explicit expressions have been derived for the response coefficients for the effect of activator and inhibitor concentrations on the fraction in the active state of the target enzyme of a monocyclic interconvertible enzyme cascade. These allow one to assess the adequacy of such a cascade for producing a highly sensitive response to an effector. Numerical studies indicate that this type of system can readily generate response coefficients of about 7, even without requiring both modification reactions to be modulated simultaneously, and without requiring all of the parameters that characterize the system to have their optimum values.
对于单环可相互转化酶级联反应中激活剂和抑制剂浓度对靶酶活性状态分数的影响，已经推导出了响应系数的显式表达式。这些表达式使人们能够评估这种级联反应对效应物产生高度敏感响应的充分性。数值研究表明，即使不需要同时调节两个修饰反应，也不需要表征该系统的所有参数都具有最佳值，这种类型的系统也能轻易产生约7的响应系数。
