Wynn D R, Rodriguez M, O'Fallon W M, Kurland L T
Department of Neurology, Mayo Clinic, Rochester, MN 55905.
Neurology. 1990 May;40(5):780-6. doi: 10.1212/wnl.40.5.780.
A review of multiple sclerosis (MS) case reports, using the unified record system at the Mayo Clinic for the Olmsted County population, revealed age- and sex-adjusted prevalence rates per 100,000 persons of 160 for Olmsted County and 173 for Rochester, Minnesota, on January 1, 1985. The annual age- and sex-adjusted incidence rate per 100,000 person-years from 1975 to 1984 for Olmsted County was 6.2 and for Rochester, 6.3. This incidence rate is significantly higher than what had been reported previously in Rochester (3.6/100,000) or in other communities. The estimated 25-year survival of the MS population was 76.2% +/- 4.5% compared with 87.7% for the general US white population of a similar age and sex. Survival for men was less than for women. There was no increase in survival for patients diagnosed with MS in more recent decades. No significant increase was found in cancer or autoimmune disease rates in the MS patients.
利用梅奥诊所针对奥尔姆斯特德县人群的统一记录系统，对多发性硬化症（MS）病例报告进行回顾后发现，1985年1月1日，奥尔姆斯特德县每10万人中经年龄和性别调整后的患病率为160，明尼苏达州罗切斯特市为173。1975年至1984年，奥尔姆斯特德县每10万人年经年龄和性别调整后的发病率为6.2，罗切斯特市为6.3。这一发病率显著高于罗切斯特市此前报告的发病率（3.6/10万）或其他社区的发病率。估计MS人群的25年生存率为76.2%±4.5%，而年龄和性别相似的美国白人总体生存率为87.7%。男性的生存率低于女性。近几十年来，被诊断为MS的患者生存率没有增加。在MS患者中，癌症或自身免疫性疾病的发病率没有显著增加。
