Nikiforova A A, Chistiakova A M, Matveev I I, Teriukova N P, Arkhipov O P
Vopr Med Khim. 1978 Jan-Feb;24(1):87-92.
On the basis of data obtained in studies on the accumulation of cholesterol in erythrocytes of newlorns, the hypothesis is advanced on the deficiency of lecithin-cholesterol-acetyl transferase (LCAT) in the newborn children. A decrease in the rate of the LCAT-reaction was shown in funic blood using the specially developed system "LP-infranatante", the constituents of which were isolated from blood plasma of both newborns and of their mothers by ultracentrifugation at a density 1.21 g/ml and 40.000 rpm. The following factors were considered as possible determinants of the decrease in the rate of cholesterol esterification in blood plasma of newborns: 1) insufficiency in LCAT, 2) alteration in the composition of the substrate lipoproteins (lipoproteins of high density).
基于对新生儿红细胞中胆固醇积累的研究获得的数据，提出了关于新生儿卵磷脂 - 胆固醇 - 乙酰转移酶（LCAT）缺乏的假说。使用专门开发的“LP - 下层液”系统，在脐血中显示了LCAT反应速率的降低，该系统的成分通过在密度为1.21 g/ml和40000转/分钟的条件下超速离心，从新生儿及其母亲的血浆中分离得到。以下因素被认为是新生儿血浆中胆固醇酯化速率降低的可能决定因素：1）LCAT不足，2）底物脂蛋白（高密度脂蛋白）组成的改变。
