Medical Department M, Aarhus University Hospital, Aarhus, Denmark.
Neuroendocrinology. 2010;92 Suppl 1:1-5. doi: 10.1159/000314297. Epub 2010 Sep 10.
Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing's syndrome in certain risk populations such as patients with type 2 diabetes or osteoporosis. The clinical implications of these observations are presently unclear. Surgery remains first line treatment for overt disease and initial cure or remission is obtained in 65-85% of patients with Cushing's disease. Late recurrences, however, occur in up to 20% and the risk does not seem to plateau even after 20 years of follow-up. A 2- to 3-fold increase in mortality is observed in most studies, and this excess mortality seems confined to patients in whom initial cure was not obtained. Cushing's syndrome continues to pose diagnostic and therapeutic challenges and life-long follow-up is mandatory.
库欣综合征（Cushing's syndrome）是一种罕见的疾病，其年发病率为 2-3/百万人，其中良性肾上腺腺瘤占 0.6/百万人。女性与男性的比例为 3:1。初步数据表明，某些高危人群（如 2 型糖尿病或骨质疏松症患者）中存在亚临床库欣综合征的高比例。这些观察结果的临床意义目前尚不清楚。手术仍然是显性疾病的一线治疗方法，库欣病患者中 65-85%的患者可获得初始治愈或缓解。然而，迟发性复发高达 20%，并且即使在 20 年的随访后，风险似乎也不会趋于平稳。大多数研究都观察到死亡率增加 2-3 倍，这种超额死亡率似乎仅限于初始治疗未获得治愈的患者。库欣综合征仍然存在诊断和治疗方面的挑战，需要终身随访。
