手性联萘基仲胺催化的醛的直接不对称溴化反应：高对映选择性和非对映选择性一锅法合成溴代醇。
Direct asymmetric bromination of aldehydes catalyzed by a binaphthyl-based secondary amine: highly enantio- and diastereoselective one-pot synthesis of bromohydrins.
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
出版信息
Chem Commun (Camb). 2010 Oct 28;46(40):7590-2. doi: 10.1039/c0cc02739a. Epub 2010 Sep 10.
PMID:20830441
Abstract
One-pot stereoselective synthesis of bromohydrins as a useful chiral building block was achieved by the reaction of Grignard reagents with optically active α-bromoaldehydes, which were in situ generated by direct asymmetric bromination of aldehydes catalyzed by a binaphthyl-based secondary amine (S)-3.
摘要
一锅法立体选择性合成溴代醇作为一种有用的手性砌块，是通过格氏试剂与光学活性的α-溴代醛反应实现的，α-溴代醛是由手性联萘酚衍生的二级胺（S）-3 催化的醛的不对称直接溴化原位生成的。
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