Sharma Suvasini, Kochar Gurpreet Singh, Sankhyan Naveen, Gulati Sheffali
Department of Pediatrics, Child Neurology Division, All India Institute of Medical Sciences, New Delhi, 110029, India.
Indian J Pediatr. 2010 Nov;77(11):1279-87. doi: 10.1007/s12098-010-0191-1. Epub 2010 Sep 10.
Coma and other states of impaired consciousness represent a medical emergency. The potential causes are numerous, and the critical window for diagnosis and effective intervention is often short. The common causes of non-traumatic coma include central nervous system infections, metabolic encephalopathy (hepatic, uremic, diabetic ketoacidosis etc.), intracranial bleed, stroke and status epilepticus. The basic principles of management include 1) Rapid assessment and stabilization, 2) Focussed clinical evaluation to assess depth of coma, localization of lesion in the central nervous system and possible clues to etiology, and 3) Treatment including general and specific measures. Commonly associated problems such as raised intracranial pressure and seizures must be recognized and managed to prevent secondary neurologic injury.
昏迷及其他意识障碍状态属于医疗急症。潜在病因众多,诊断和有效干预的关键窗口期往往较短。非创伤性昏迷的常见病因包括中枢神经系统感染、代谢性脑病(肝性、尿毒症性、糖尿病酮症酸中毒等)、颅内出血、中风和癫痫持续状态。处理的基本原则包括:1)快速评估与稳定病情;2)针对性的临床评估,以评估昏迷深度、中枢神经系统病变的定位以及可能的病因线索;3)治疗,包括一般措施和特殊措施。必须识别并处理常见的相关问题,如颅内压升高和癫痫发作,以防止继发性神经损伤。