非创伤性昏迷的发病率、病因及转归：一项基于人群的研究。
Incidence, aetiology, and outcome of non-traumatic coma: a population based study.
作者信息
Wong C P, Forsyth R J, Kelly T P, Eyre J A
机构信息
Paediatric Neuroscience Group, Department of Child Health, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne NE1 4LP, UK.
出版信息
Arch Dis Child. 2001 Mar;84(3):193-9. doi: 10.1136/adc.84.3.193.
AIM
To determine the incidence, presentation, aetiology, and outcome of non-traumatic coma in children aged between 1 month and 16 years.
METHODS
In this prospective, population based, epidemiological study in the former Northern NHS region of the UK, cases were notified following any hospital admission or community death associated with non-traumatic coma. Coma was defined as a Glasgow Coma Score below 12 for more than six hours.
RESULTS
The incidence of non-traumatic coma was 30.8 per 100 000 children under 16 per year (6.0 per 100 000 general population per year). The age specific incidence was notably higher in the first year of life (160 per 100 000 children per year). CNS specific presentations became commoner with increasing age. In infants, nearly two thirds of presentations were with non-specific, systemic signs. Infection was the commonest overall aetiology. Aetiology remained unknown in 14% despite extensive investigation and/or autopsy. Mortality was highly dependent on aetiology, with aetiology specific mortality rates varying from 3% to 84%. With follow up to approximately 12 months, overall series mortality was 46%.
目的
确定1个月至16岁儿童非创伤性昏迷的发病率、临床表现、病因及预后。
方法
在英国原北部国民保健服务（NHS）地区进行的这项基于人群的前瞻性流行病学研究中，在出现与非创伤性昏迷相关的任何医院入院或社区死亡情况后报告病例。昏迷定义为格拉斯哥昏迷评分低于12分且持续超过6小时。
结果
16岁以下儿童非创伤性昏迷的发病率为每年每10万名儿童中有30.8例（每年每10万普通人群中有6.0例）。一岁以内儿童的年龄别发病率显著更高（每年每10万名儿童中有160例）。中枢神经系统特异性表现随年龄增长而更为常见。在婴儿中，近三分之二的临床表现为非特异性的全身症状。感染是最常见的总体病因。尽管进行了广泛的调查和/或尸检，但仍有14%的病因不明。死亡率高度依赖于病因，病因特异性死亡率从3%到84%不等。随访约12个月时，总体系列死亡率为46%。
Zotero 插件