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腹腔注射卤代苯后小鼠骨髓嗜多染红细胞微核的诱导

[Induction of micronuclei in polychromatic erythrocytes from mouse bone marrow following intraperitoneal administration of halogenated benzenes].

作者信息

Parrini M, Bolognesi C, Roggieri P

机构信息

Istituto Nazionale per la Ricerca sul Cancro, Genova.

出版信息

Boll Soc Ital Biol Sper. 1990 Jul;66(7):709-16.

PMID:2083065
Abstract

The mutagenicity of halogenated benzenes, including three isomers of tri- and tetrachlorobenzenes (TCB, TeCB) was studied on male Swiss CD1 mice by MN test. The data presented show that all the halogenated benzenes tested were found to be clastogenic apart from 1,2,3,5-TeCB. No significant differences were observed in the clastogenic activities of TCB-isomers and TeCB-isomers.

摘要

通过微核试验,对包括三氯苯和四氯苯(TCB,TeCB)的三种异构体在内的卤代苯的致突变性进行了雄性瑞士CD1小鼠研究。所呈现的数据表明,除1,2,3,5-TeCB外,所有测试的卤代苯均具有致断裂性。在TCB异构体和TeCB异构体的致断裂活性方面未观察到显著差异。

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