海藻酸钠作为粘度调节剂可能会诱导红细胞聚集。

Sodium alginate as viscosity modifier may induce aggregation of red blood cells.

作者信息

Zhao Lian, You Guoxing, Liao Fulong, Kan Xuemei, Wang Bo, Sun Quanmei, Xu Huibin, Han Dong, Zhou Hong

机构信息

Department of Immunohematology, Beijing Institute of Transfusion Medicine, Beijing, China.

出版信息

Artif Cells Blood Substit Immobil Biotechnol. 2010 Oct;38(5):267-76. doi: 10.3109/10731191003776736.

DOI:10.3109/10731191003776736

PMID:20831352

Abstract

Viscosity of blood substitutes is among the important determinants to restore microcirculation. Sodium alginate (SA) is always mentioned as "viscosity modifier" in creating blood substitutes. In the present study, the whole blood was diluted using SA solutions to final hematocrits of 10%, 20%, and 35%, respectively. The whole blood viscosity (WBV) at different shear rates, plasma viscosity (PV), and rheological behavior of red blood cells (RBCs) was studied in vitro. The results show that SA may induce RBCs aggregation in a dose-dependent manner. Furthermore, the effect of SA on RBCs aggregation maybe involve the regulation of microcirculation.

摘要

血液替代品的粘度是恢复微循环的重要决定因素之一。在制备血液替代品时，海藻酸钠（SA）常被提及为“粘度调节剂”。在本研究中，分别用SA溶液将全血稀释至最终血细胞比容为10%、20%和35%。体外研究了不同剪切速率下的全血粘度（WBV）、血浆粘度（PV）以及红细胞（RBC）的流变行为。结果表明，SA可能以剂量依赖的方式诱导RBC聚集。此外，SA对RBC聚集的影响可能涉及微循环的调节。