Chemical and Biological Engineering, University of Ottawa, Ottawa, Ontario, Canada.
PLoS One. 2013 Aug 30;8(8):e72909. doi: 10.1371/journal.pone.0072909. eCollection 2013.
It is desired to understand the effect of alginic acid sodium salt from brown algae (alginate) as a viscosity modifier on the behavior of blood in vitro using a micro-particle image velocimetry (µPIV) system. The effect of alginate on the shape of the velocity profile, the flow rate and the maximum velocity achieved in rectangular microchannels channels are measured. The channels were constructed of polydimethylsiloxane (PDMS), a biocompatible silicone. Porcine blood cells suspended in saline was used as the working fluid at twenty percent hematocrit (H = 20). While alginate was only found to have minimal effect on the maximum velocity and the flow rate achieved, it was found to significantly affect the shear rate at the wall by between eight to a hundred percent.
本研究旨在利用微粒子图像测速（µPIV）系统，了解来自褐藻（褐藻胶）的海藻酸钠作为黏度改性剂对体外血液行为的影响。测量了海藻酸钠对矩形微通道中速度剖面形状、流速和达到的最大速度的影响。通道由聚二甲基硅氧烷（PDMS）构建，这是一种生物相容性硅酮。以 20%的红细胞比容（H = 20）的生理盐水悬浮猪血细胞作为工作流体。虽然海藻酸钠仅对达到的最大速度和流速有最小的影响，但研究发现它对壁面处的剪切率有 8%至 100%的显著影响。
