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本文引用的文献

1
Cost sharing and the initiation of drug therapy for the chronically ill.成本分担与慢性病药物治疗的启动
Arch Intern Med. 2009 Apr 27;169(8):740-8; discussion 748-9. doi: 10.1001/archinternmed.2009.62.
2
Prescription drug cost sharing: associations with medication and medical utilization and spending and health.处方药费用分担:与药物使用、医疗利用、支出及健康的关联
JAMA. 2007 Jul 4;298(1):61-9. doi: 10.1001/jama.298.1.61.
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Benefit design and specialty drug use.福利设计与专科药物使用。
Health Aff (Millwood). 2006 Sep-Oct;25(5):1319-31. doi: 10.1377/hlthaff.25.5.1319.
4
Varying pharmacy benefits with clinical status: the case of cholesterol-lowering therapy.根据临床状况调整药房福利:以降胆固醇治疗为例。
Am J Manag Care. 2006 Jan;12(1):21-8.
5
Impact of medication adherence on hospitalization risk and healthcare cost.药物依从性对住院风险和医疗费用的影响。
Med Care. 2005 Jun;43(6):521-30. doi: 10.1097/01.mlr.0000163641.86870.af.
6
Medicaid cost containment and access to prescription drugs.医疗补助费用控制与处方药获取
Health Aff (Millwood). 2005 May-Jun;24(3):780-9. doi: 10.1377/hlthaff.24.3.780.
7
Accuracy of Veterans Administration databases for a diagnosis of rheumatoid arthritis.退伍军人管理局数据库对类风湿性关节炎诊断的准确性。
Arthritis Rheum. 2004 Dec 15;51(6):952-7. doi: 10.1002/art.20827.
8
Anti-TNF-alpha therapies: they are all the same (aren't they?).抗肿瘤坏死因子-α疗法:它们都一样(不是吗?)
Rheumatology (Oxford). 2005 Mar;44(3):271-3. doi: 10.1093/rheumatology/keh483. Epub 2004 Nov 23.
9
Pharmacy benefits and the use of drugs by the chronically ill.药房福利与慢性病患者的药物使用
JAMA. 2004 May 19;291(19):2344-50. doi: 10.1001/jama.291.19.2344.
10
The effect of incentive-based formularies on prescription-drug utilization and spending.基于激励措施的药品处方集对处方药使用及支出的影响。
N Engl J Med. 2003 Dec 4;349(23):2224-32. doi: 10.1056/NEJMsa030954.

费用分担、家庭医疗负担与类风湿性关节炎专科药物的使用。

Cost sharing, family health care burden, and the use of specialty drugs for rheumatoid arthritis.

机构信息

School of Public Health, University of Minnesota, 420 Deleware Street SE, MMC729, Minneapolis, MN 55455, USA.

出版信息

Health Serv Res. 2010 Oct;45(5 Pt 1):1227-50. doi: 10.1111/j.1475-6773.2010.01117.x.

DOI:10.1111/j.1475-6773.2010.01117.x
PMID:20831715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2965502/
Abstract

OBJECTIVES

To examine the impact of benefit generosity and household health care financial burden on the demand for specialty drugs in the treatment of rheumatoid arthritis (RA).

DATA SOURCES/STUDY SETTING: Enrollment, claims, and benefit design information for 35 large private employers during 2000-2005.

STUDY DESIGN

We estimated multivariate models of the effects of benefit generosity and household financial burden on initiation and continuation of biologic therapies.

DATA EXTRACTION METHODS

We defined initiation of biologic therapy as first-time use of etanercept, adalimumab, or infliximab, and we constructed an index of plan generosity based on coverage of biologic therapies in each plan. We estimated the household's burden by summing up the annual out-of-pocket (OOP) expenses of other family members.

PRINCIPAL FINDINGS

Benefit generosity affected both the likelihood of initiating a biologic and continuing drug therapy, although the effects were stronger for initiation. Initiation of a biologic was lower in households where other family members incurred high OOP expenses.

CONCLUSIONS

The use of biologic therapy for RA is sensitive to benefit generosity and household financial burden. The increasing use of coinsurance rates for specialty drugs (as under Medicare Part D) raises concern about adverse health consequences.

摘要

目的

考察福利慷慨程度和家庭医疗保健财务负担对类风湿关节炎(RA)治疗中专科药物需求的影响。

数据来源/研究环境:2000-2005 年间 35 家大型私营雇主的注册、索赔和福利设计信息。

研究设计

我们估计了福利慷慨程度和家庭经济负担对生物疗法起始和持续使用的多变量模型。

数据提取方法

我们将生物疗法的起始定义为依那西普、阿达木单抗或英夫利昔单抗的首次使用,并根据每个计划中生物疗法的覆盖范围构建了计划慷慨指数。我们通过汇总其他家庭成员的年度自付(OOP)费用来计算家庭负担。

主要发现

福利慷慨程度既影响生物药物的起始使用,也影响药物治疗的持续使用,但对起始使用的影响更强。其他家庭成员 OOP 费用较高的家庭,使用生物药物的可能性较低。

结论

RA 生物疗法的使用对福利慷慨程度和家庭财务负担敏感。特种药物(如医疗保险 D 部分)越来越多地采用共付额费率,这令人担忧会对健康产生不利后果。