School of Public Health, University of Minnesota, 420 Deleware Street SE, MMC729, Minneapolis, MN 55455, USA.
Health Serv Res. 2010 Oct;45(5 Pt 1):1227-50. doi: 10.1111/j.1475-6773.2010.01117.x.
To examine the impact of benefit generosity and household health care financial burden on the demand for specialty drugs in the treatment of rheumatoid arthritis (RA).
DATA SOURCES/STUDY SETTING: Enrollment, claims, and benefit design information for 35 large private employers during 2000-2005.
We estimated multivariate models of the effects of benefit generosity and household financial burden on initiation and continuation of biologic therapies.
We defined initiation of biologic therapy as first-time use of etanercept, adalimumab, or infliximab, and we constructed an index of plan generosity based on coverage of biologic therapies in each plan. We estimated the household's burden by summing up the annual out-of-pocket (OOP) expenses of other family members.
Benefit generosity affected both the likelihood of initiating a biologic and continuing drug therapy, although the effects were stronger for initiation. Initiation of a biologic was lower in households where other family members incurred high OOP expenses.
The use of biologic therapy for RA is sensitive to benefit generosity and household financial burden. The increasing use of coinsurance rates for specialty drugs (as under Medicare Part D) raises concern about adverse health consequences.
考察福利慷慨程度和家庭医疗保健财务负担对类风湿关节炎(RA)治疗中专科药物需求的影响。
数据来源/研究环境:2000-2005 年间 35 家大型私营雇主的注册、索赔和福利设计信息。
我们估计了福利慷慨程度和家庭经济负担对生物疗法起始和持续使用的多变量模型。
我们将生物疗法的起始定义为依那西普、阿达木单抗或英夫利昔单抗的首次使用,并根据每个计划中生物疗法的覆盖范围构建了计划慷慨指数。我们通过汇总其他家庭成员的年度自付(OOP)费用来计算家庭负担。
福利慷慨程度既影响生物药物的起始使用,也影响药物治疗的持续使用,但对起始使用的影响更强。其他家庭成员 OOP 费用较高的家庭,使用生物药物的可能性较低。
RA 生物疗法的使用对福利慷慨程度和家庭财务负担敏感。特种药物(如医疗保险 D 部分)越来越多地采用共付额费率,这令人担忧会对健康产生不利后果。