Kaye G C, Mehta D, Wafa S, Camm A J
Department of Cardiovascular Studies, St. George's Hospital, Medical School, London, UK.
Cardiovasc Drugs Ther. 1990 Aug;4(4):1157-60. doi: 10.1007/BF01856513.
The acute electrophysiologic effects of an intravenous bolus of ketanserin, a 5HT2 serotonin blocker, were studied in ten patients (four females, six males) during invasive electrophysiology. Following baseline electrophysiologic measurements during sinus rhythm and fixed-rate atrial pacing at 600 ms, a bolus of 0.2 mg/kg ketanserin was given over a 3-minute period. After 30 minutes all measurements were repeated. Systemic blood pressure was measured at regular intervals throughout. During sinus rhythm, there was no significant change in the basic cycle length or in the PA, AH, HV, QRS, QT, and QTc intervals. During atrial pacing there was a nonsignificant increase in the QT interval, from 342 +/- 13 ms to 366 +/- 16 ms, and a significant increase in the QTc interval, from 422 +/- 27 ms to 449 +/- 29 ms (p less than 0.05). There was no reduction in blood pressure. Thus ketanserin produced a significant prolongation of the QTc interval, in the absence of hypokalemia, in humans.
在侵入性电生理检查过程中，对10例患者（4例女性，6例男性）研究了静脉注射5HT2血清素阻滞剂酮色林的急性电生理效应。在窦性心律和600毫秒的固定频率心房起搏期间进行基线电生理测量后，在3分钟内静脉推注0.2毫克/千克的酮色林。30分钟后重复所有测量。在整个过程中定期测量全身血压。在窦性心律期间，基本周期长度或PA、AH、HV、QRS、QT和QTc间期均无显著变化。在心房起搏期间，QT间期从342±13毫秒非显著增加至366±16毫秒，QTc间期从422±27毫秒显著增加至449±29毫秒（p<0.05）。血压没有降低。因此，在无低钾血症的情况下，酮色林可使人类QTc间期显著延长。
