Drake-Holland A J, Noble M I, Pugh S, Mills C
Department of Medicine 1, St. George's Hospital Medical School, London, England.
Cardiovasc Drugs Ther. 1988 Jul;2(2):239-43. doi: 10.1007/BF00051240.
In this study any changes in action potential duration or Q-T interval due to acute doses of ketanserin were monitored. The effect of a bolus dose (10 or 20 mg) followed by an infusion (10 or 20 mg over 20 minutes) of ketanserin on the Q-T interval and action potential duration was studied in six patients undergoing routine cardiac catheterization. Action potential duration was measured with a silver-silver chloride electrode catheter while heart rate was kept constant by atrial pacing and reflex effects avoided by beta-adrenergic blockade. There were some prolongations of the action potential duration but they were not in excess of 40 msec and did not reach statistical significance (control 263 +/- 46.0 msec; bolus 269 +/- 52.1 msec; infusion 262 +/- 53.6 msec; nor were there any significant changes in Q-T interval. Thus acute intravenous doses of ketanserin, in the absence of hypokalaemia or other Q-T interval-prolonging drugs, have no consistent effect on Q-T interval or action potential duration; prolongation of the action potential, when it occurs, is small.
在本研究中，监测了急性剂量的酮色林对动作电位持续时间或Q-T间期的任何变化。在6例接受常规心导管检查的患者中，研究了静脉推注剂量（10或20 mg）随后输注（20分钟内10或20 mg）酮色林对Q-T间期和动作电位持续时间的影响。通过银-氯化银电极导管测量动作电位持续时间，同时通过心房起搏保持心率恒定，并通过β-肾上腺素能阻滞剂避免反射效应。动作电位持续时间有一些延长，但不超过40毫秒，且未达到统计学显著性（对照组263±46.0毫秒；推注组269±52.1毫秒；输注组262±53.6毫秒），Q-T间期也没有任何显著变化。因此，在没有低钾血症或其他延长Q-T间期药物的情况下，急性静脉注射剂量的酮色林对Q-T间期或动作电位持续时间没有一致的影响；动作电位延长时，幅度较小。
