Bella A F, Adetuyibi A
Department of Medicine, University College Hospital, Ibadan.
West Afr J Med. 1990 Oct-Dec;9(4):291-4.
The levels of insulin antibodies were determined in 68 diabetic patients on insulin treatment and 30 normal subjects. Fifty (73.5%) of the patients had low levels of insulin antibodies (less than 20%), twelve (17.7%) had moderate levels (between 20 and 40%) while the remaining six (8.8%) had high antibody levels (greater than 40%). There was poor correlation of insulin antibody level with insulin dose (r = 0.16, p less than 0.1) and with duration of disease (r = 0.19, p less than 0.5). Where high levels of antibodies were detected the problems encountered in treating the patients with highly purified insulin preparations are discussed.
对68例接受胰岛素治疗的糖尿病患者和30名正常受试者测定了胰岛素抗体水平。50例（73.5%）患者胰岛素抗体水平较低（低于20%），12例（17.7%）患者抗体水平中等（20%至40%之间），其余6例（8.8%）患者抗体水平较高（大于40%）。胰岛素抗体水平与胰岛素剂量（r = 0.16，p<0.1）以及病程（r = 0.19，p<0.5）之间的相关性较差。文中讨论了在检测到高水平抗体的情况下，使用高纯度胰岛素制剂治疗患者时遇到的问题。
