Stögmann W, Statz H
Padiatr Padol. 1980;15(4):385-92.
This is a report about the findings of insulin antibody formation (circulating IgG-antibodies) in 18 diabetic children. 1. High levels of antibodies during treatment with conventional insulin show a remarkable decrease under treatment with highly-purified insulins. 2. Insulin binding capacities were also found in children treated from diagnosis of the disease with highly-purified insulins, but they were all below 1.0 mU/ml. 3. Infectious diseases and intermittent insulin application seem to provoke an, at least briefly, increase of antibodies. 4. High levels of antibodies cause a high insulin requirement. Therefore only highly-purified insulin should be used for the treatment of childhood onset diabetes mellitus.
这是一份关于18名糖尿病儿童胰岛素抗体形成（循环IgG抗体）的研究报告。1. 常规胰岛素治疗期间抗体水平较高，而在使用高纯度胰岛素治疗时显著下降。2. 在疾病诊断后即开始使用高纯度胰岛素治疗的儿童中也发现了胰岛素结合能力，但均低于1.0 mU/ml。3. 传染病和间歇性胰岛素应用似乎至少会短暂地引发抗体增加。4. 高抗体水平导致胰岛素需求量增加。因此，儿童期起病的糖尿病 mellitus治疗应仅使用高纯度胰岛素。
