Remy P
Département de Neurosciences, Pôle Neurolocomoteur, CHU Henri-Mondor, 51 Avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil Cedex, France.
Rev Neurol (Paris). 2010 Oct;166(10):770-4. doi: 10.1016/j.neurol.2010.07.018. Epub 2010 Sep 15.
Functional imaging is a tool that has been long restricted to research programs. However, the availability of ¹²³I-Ioflupane SPECT imaging has developed its' clinical utilization with a risk of misuse. There is room for improvement for the differential diagnosis between idiopathic Parkinson's disease (PD) and atypical parkinsonian syndromes and the measure of brain glucose metabolism with PET might fill this gap in the future. Conversely, functional imaging is still a major tool for the evaluation of new experimental therapeutic strategies in PD, especially for those aiming at restoring or protecting striatal dopaminergic innervation.
功能成像一直是一种长期局限于研究项目的工具。然而，¹²³I-碘氟潘单光子发射计算机断层显像（SPECT）成像的应用拓展了其临床用途，但存在被滥用的风险。在特发性帕金森病（PD）与非典型帕金森综合征的鉴别诊断方面仍有改进空间，正电子发射断层显像（PET）测量脑葡萄糖代谢可能在未来填补这一空白。相反，功能成像仍是评估PD新实验性治疗策略的主要工具，尤其是针对旨在恢复或保护纹状体多巴胺能神经支配的策略。
