Piccini Paola, Whone Alan
MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK.
Lancet Neurol. 2004 May;3(5):284-90. doi: 10.1016/S1474-4422(04)00736-7.
The accurate diagnosis of idiopathic Parkinson's disease (IPD) is not only important for deciding on treatment strategies and providing a prognosis, but also crucial for studies designed to investigate the aetiology and pathogenesis of parkinsonian disorders. Over recent decades, improvements in the characterisation of the parkinsonian syndromes have led to improvements in clinical diagnostic accuracy; however, clinical criteria alone are not always sufficient to distinguish between IPD and other parkinsonian syndromes, particularly in the early stages of disease and in atypical presentations. Therefore, in addition to the development and implementation of diagnostic clinical assessments, there is a need for available objective markers to aid the physician in the differential diagnosis of IPD. Functional neuroimaging holds the promise of improved diagnosis and allows assessment in early disease. In this review, the use of PET and single photon emission CT in the differential diagnosis of IPD are discussed.
准确诊断特发性帕金森病（IPD）不仅对于确定治疗策略和提供预后至关重要，而且对于旨在研究帕金森病病因和发病机制的研究也至关重要。近几十年来，帕金森综合征特征描述的改进提高了临床诊断准确性；然而，仅靠临床标准并不总是足以区分IPD和其他帕金森综合征，特别是在疾病早期和非典型表现中。因此，除了开发和实施诊断性临床评估外，还需要可用的客观标志物来帮助医生进行IPD的鉴别诊断。功能神经影像学有望改善诊断并允许在疾病早期进行评估。在这篇综述中，讨论了PET和单光子发射CT在IPD鉴别诊断中的应用。
