溶瘤性牛痘病毒的免疫调节特性及其在治疗学中的意义。
The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics.
机构信息
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Rd, P.O. box 100266, Gainesville, FL 32610, USA.
出版信息
Microbes Infect. 2010 Dec;12(14-15):1144-52. doi: 10.1016/j.micinf.2010.08.012. Epub 2010 Sep 9.
Abstract
Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.
摘要
粘液瘤病毒（MYXV）是一种严格的兔源痘病毒，对发病机制具有特异性宿主趋向性。MYXV 编码的免疫调节因子可以抑制来自其他物种的免疫效应物的某些功能。我们综述了它们的作用机制、在治疗中的意义以及提高 MYXV 作为人类溶瘤剂的潜力。
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