Animal Production Research Centre Nitra, 951 41 Lužianky near Nitra, Slovakia.
Int J Biochem Cell Biol. 2010 Dec;42(12):1927-30. doi: 10.1016/j.biocel.2010.08.018. Epub 2010 Sep 15.
The present focus survey represents a review of current knowledge concerning involvement of protein kinases in control of basic ovarian functions in mammals. Ovarian cells produce a number of protein kinases, whose expression depends on type of cells, their state and action of hormones and other protein kinases. A number of protein kinases are involved in control of ovarian cell proliferation, apoptosis, oocyte maturation, hormone release, reception and response to hormones, as well as in mediating action of hormones on these ovarian functions. Protein kinases and their regulators could be used for characterization, prediction and control of ovarian folliculogenesis and atresia, corpus luteum functions, oocyte maturation, fertility, release of hormones, response of ovarian structures to hormonal regulators, as well as for treatment of some reproductive disorders.
目前的焦点调查代表了对当前知识的回顾，涉及蛋白激酶在控制哺乳动物基本卵巢功能中的作用。卵巢细胞产生多种蛋白激酶，其表达取决于细胞类型、细胞状态以及激素和其他蛋白激酶的作用。许多蛋白激酶参与控制卵巢细胞的增殖、凋亡、卵母细胞成熟、激素释放、激素的接受和反应，以及激素对这些卵巢功能的作用。蛋白激酶及其调节剂可用于描述、预测和控制卵巢卵泡发生和闭锁、黄体功能、卵母细胞成熟、生育能力、激素释放、卵巢结构对激素调节剂的反应，以及治疗某些生殖障碍。
