Animal Production Research Centre Lužianky near Nitra, Nitra, Slovakia.
J Cell Physiol. 2011 Sep;226(9):2222-5. doi: 10.1002/jcp.22588.
The present review demonstrates an important role of different growth factors (of insulin-like growth factors, epidermal growth factors, vascular endothelial growth factor, thrombopoietin, erytropoietin, hepatocyte growth factor, and growth factors of Hedgehog, Wnt and Notch families) in control of different ovarian functions--ovarian cell proliferation, apoptosis, folliculogenesis, luteogenesis, oogenesis, release of hormones, response to upstream hormonal regulators, fertility and, in some cases, in development of ovarian disorders. The possibility of practical application of these growth factors for characterization, prediction, and regulation the ovarian state is demonstrated.
本综述表明，不同生长因子（胰岛素样生长因子、表皮生长因子、血管内皮生长因子、血小板生成素、促红细胞生成素、肝细胞生长因子，以及 Hedgehog、Wnt 和 Notch 家族的生长因子）在控制卵巢的不同功能（卵巢细胞增殖、凋亡、卵泡发生、黄体生成、卵子发生、激素释放、对上游激素调节剂的反应、生育能力以及在某些情况下卵巢疾病的发展）方面发挥着重要作用。本文还展示了这些生长因子在卵巢状态的特征描述、预测和调控方面的实际应用的可能性。
