Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH1015 Lausanne, Switzerland.
Dev Cell. 2010 Sep 14;19(3):360-2. doi: 10.1016/j.devcel.2010.08.018.
Calo et al. (2010) recently reported that the absence of the transcriptional regulator pRb enhances differentiation of mesenchymal precursors toward the brown adipocyte lineage in detriment of osteoblast and white fat populations. These findings may have therapeutic implications for cancer and bone and metabolic disease.
Calo 等人（2010 年）最近报道称，转录调节因子 pRb 的缺失会增强间充质前体细胞向棕色脂肪细胞谱系的分化，而不利于成骨细胞和白色脂肪细胞群体。这些发现可能对癌症、骨骼和代谢疾病具有治疗意义。
