精神运动阻滞是否定义了单相抑郁的一种具有临床意义的表型？
Does psychomotor retardation define a clinically relevant phenotype of unipolar depression?
机构信息
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, School of Medicine, University of Pisa, Italy.
出版信息
J Affect Disord. 2011 Mar;129(1-3):296-300. doi: 10.1016/j.jad.2010.08.004. Epub 2010 Sep 15.
BACKGROUND
The recognition and assessment of psychomotor retardation may have implications for better definition of the clinical phenotypes of depression. The aim of this study was to assess the clinical correlates of psychomotor retardation endorsed at any time during the patients' lifetime (LPR).
METHODS
The study sample included 291 patients with non-psychotic major depressive disorder (MDD) participating in the clinical trial, "Depression: The Search for Treatment-Relevant Phenotypes." Psychomotor retardation was measured using a factor derived from the Mood Spectrum Self-Report (MOODS-SR) assessment. Using a pre-defined cut-off score on the lifetime psychomotor retardation (LPR) factor of the MOODS-SR, participants were classified into high and low scorers. Logistic regression analysis was used to evaluate the relationship between LPR and subthreshold bipolarity.
RESULTS
Compared to low scorers, participants with high scores on the LPR factor had greater severity of depression and more bipolarity indicators.
CONCLUSIONS
The MOODS-SR appears to be helpful to identify clinical phenotypes of unipolar depression and to highlight the usefulness of a lifetime approach to the assessment of psychopathology in the characterisation of patients with unipolar depression.
背景
识别和评估精神运动迟缓可能对更好地定义抑郁症的临床表型具有重要意义。本研究旨在评估在患者一生中任何时候（LPR）所认可的精神运动迟缓的临床相关性。
方法
研究样本包括 291 名参加临床试验“抑郁：寻找与治疗相关的表型”的非精神病性重度抑郁症（MDD）患者。使用源自情绪谱自我报告（MOODS-SR）评估的因子来测量精神运动迟缓。使用 MOODS-SR 的终生精神运动迟缓（LPR）因子的预定义截断分数，将参与者分为高得分者和低得分者。使用逻辑回归分析评估 LPR 与亚阈值双相性之间的关系。
结果
与低得分者相比，LPR 因子得分较高的参与者的抑郁严重程度更高，双相性指标更多。
结论
MOODS-SR 似乎有助于识别单相抑郁的临床表型，并突出了终生评估精神病理学在单相抑郁患者特征描述中的有用性。
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