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[低剂量外照射γ射线后成熟及老龄大鼠心肌细胞氧化还原酶的组织化学分析]

[A histochemical analysis of the oxidative-reductive enzymes in the cardiomyocytes of mature and old rats following low-dose external gamma irradiation].

作者信息

Ambros'ev A P, Vereshchako G G, Banetskaia N V

出版信息

Biull Eksp Biol Med. 1990 Nov;110(11):548-50.

PMID:2083345
Abstract

The effect of gamma rays in low dose (0.5 Gy) on enzymes activity of glycolysis, tricarboxylic acid cycle, diaphorases in cardiomyocytes of adult and old albino rats at 3-, 10- and 30-day after irradiation was studied. It was established that the diaphorases activity decreased, the lactate dehydrogenase activity increased whereas that of other tricarboxylic acid cycle enzymes underwent phase changes. In result discoordination of redox enzymes in cardiomyocytes of rats hypoxic state develops. The question of the age sensitivity of heart to irradiation in low dose is discussed.

摘要

研究了低剂量(0.5戈瑞)γ射线对成年和老年白化大鼠心肌细胞糖酵解、三羧酸循环、黄递酶的酶活性在照射后3天、10天和30天的影响。结果表明,黄递酶活性降低,乳酸脱氢酶活性增加,而其他三羧酸循环酶的活性则发生阶段性变化。结果导致大鼠心肌细胞缺氧状态下氧化还原酶的失调。讨论了心脏对低剂量辐射的年龄敏感性问题。

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