Kossoff Eric H, Dorward Jennifer L, Turner Zahava, Pyzik Paula L
The John M. Freeman Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
J Child Neurol. 2011 Feb;26(2):147-51. doi: 10.1177/0883073810375718. Epub 2010 Sep 10.
The modified Atkins diet is a high-fat, low-carbohydrate treatment for intractable childhood epilepsy. As data suggest that a stricter diet onset can be more effective, we added a ketogenic supplement to the modified Atkins diet during its initial month. Thirty children with intractable epilepsy were prospectively started on the modified Atkins diet in combination with a daily 400-calorie KetoCal shake. At 1 month, 24 (80%) children had >50% seizure reduction, of which 11 (37%) had >90% seizure reduction. There was no significant loss of efficacy during the second month after KetoCal was discontinued. The use of this ketogenic supplement increased daily fat intake and thus the ketogenic ratio (1.8:1 versus 1.0:1 in the modified Atkins diet alone, P = .0002), but did not change urinary or serum ketosis. The addition of a ketogenic supplement to the modified Atkins diet during its initial month appears to be beneficial.
改良阿特金斯饮食法是一种针对儿童难治性癫痫的高脂肪、低碳水化合物疗法。由于数据表明更严格的饮食起始方式可能更有效，我们在改良阿特金斯饮食法的首个月添加了一种生酮补充剂。30名患有难治性癫痫的儿童前瞻性地开始采用改良阿特金斯饮食法，并每日饮用400卡路里的酮基奶粉奶昔。1个月时，24名（80%）儿童癫痫发作减少>50%，其中11名（37%）癫痫发作减少>90%。在停用酮基奶粉后的第二个月，疗效没有显著下降。这种生酮补充剂的使用增加了每日脂肪摄入量，从而提高了生酮比例（单独使用改良阿特金斯饮食法时为1.0:1，添加补充剂后为1.8:1，P = .0002），但并未改变尿酮或血酮水平。在改良阿特金斯饮食法的首个月添加生酮补充剂似乎是有益的。
