Kossoff Eric H, Turner Zahava, Bluml Renee M, Pyzik Paula L, Vining Eileen P G
The Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Epilepsy Behav. 2007 May;10(3):432-6. doi: 10.1016/j.yebeh.2007.01.012. Epub 2007 Feb 26.
The modified Atkins diet is a dietary therapy for intractable epilepsy that mimics the ketogenic diet, yet does not restrict protein, calories, and fluids. The ideal starting carbohydrate limit is unknown. Twenty children with intractable epilepsy were randomized to either 10 or 20 g of carbohydrates per day for the initial 3 months of the modified Atkins diet, and then crossed over to the opposite amount. A significantly higher likelihood of >50% seizure reduction was noted for children started on 10 g of carbohydrate per day at 3 months: 60% versus 10% (P=0.03). Most parents reported no change in seizure frequency or ketosis between groups, but improved tolerability with 20 g per day. A starting carbohydrate limit of 10 g per day for children starting the modified Atkins diet may be ideal, with a planned increase to a more tolerable 20 g per day after 3 months.
改良阿特金斯饮食是一种针对难治性癫痫的饮食疗法，它模仿生酮饮食，但不限制蛋白质、热量和液体摄入。理想的起始碳水化合物限量尚不清楚。20名难治性癫痫患儿被随机分为两组，在改良阿特金斯饮食的最初3个月里，一组每天摄入10克碳水化合物，另一组每天摄入20克碳水化合物，之后两组交叉互换摄入量。结果发现，在3个月时，开始每天摄入10克碳水化合物的儿童癫痫发作减少>50%的可能性显著更高：60% 对比10%（P = 0.03）。大多数家长报告称，两组之间癫痫发作频率或酮症没有变化，但每天摄入20克碳水化合物时耐受性有所改善。对于开始采用改良阿特金斯饮食的儿童，每天10克的起始碳水化合物限量可能是理想的，3个月后计划增加到更易耐受的每天20克。
