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脂质 A 脱酰酶 PagL 的潜伏期参与了沙门氏菌外膜中强大渗透屏障的产生。

Latency of the lipid A deacylase PagL is involved in producing a robust permeation barrier in the outer membrane of Salmonella enterica.

机构信息

Faculty of Pharmaceutical Sciences, Doshisha Women's College, Kyotanabe 610-0395, Japan.

出版信息

J Bacteriol. 2010 Nov;192(21):5837-40. doi: 10.1128/JB.00758-10. Epub 2010 Sep 10.

DOI:10.1128/JB.00758-10
PMID:20833808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2953691/
Abstract

Lipid A deacylase PagL, which detoxifies endotoxin, is latent in Salmonella enterica. This study determined the biological significance of this latency. PagL latency was beneficial for bacteria in producing a robust permeation barrier through lipid A modifications under host-mimetic conditions that induced the modification enzymes, including PagL.

摘要

脂质 A 脱酰酶 PagL 能够解毒内毒素，潜伏在沙门氏菌中。本研究确定了这种潜伏的生物学意义。在诱导包括 PagL 在内的修饰酶的宿主模拟条件下，PagL 潜伏有利于细菌通过脂质 A 修饰产生强大的渗透屏障。

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Latency of the lipid A deacylase PagL is involved in producing a robust permeation barrier in the outer membrane of Salmonella enterica.脂质 A 脱酰酶 PagL 的潜伏期参与了沙门氏菌外膜中强大渗透屏障的产生。
J Bacteriol. 2010 Nov;192(21):5837-40. doi: 10.1128/JB.00758-10. Epub 2010 Sep 10.
2
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本文引用的文献

1
Mutations in the lipid A deacylase PagL which release the enzyme from its latency affect the ability of PagL to interact with lipopolysaccharide in Salmonella enterica serovar Typhimurium.脂质 A 脱酰酶 PagL 中的突变使其从潜伏状态中释放出来，从而影响 PagL 与沙门氏菌属 Typhimurium 脂多糖相互作用的能力。
Biochem Biophys Res Commun. 2010 Jun 11;396(4):812-6. doi: 10.1016/j.bbrc.2010.04.153. Epub 2010 May 11.
2
Extracellular loops of lipid A 3-O-deacylase PagL are involved in recognition of aminoarabinose-based membrane modifications in Salmonella enterica serovar typhimurium.脂质A 3-O-脱酰酶PagL的细胞外环参与鼠伤寒沙门氏菌中基于氨基阿拉伯糖的膜修饰的识别。
J Bacteriol. 2008 Aug;190(16):5597-606. doi: 10.1128/JB.00587-08. Epub 2008 Jun 20.
3
Structural biology of membrane-intrinsic beta-barrel enzymes: sentinels of the bacterial outer membrane.膜内在β-桶状酶的结构生物学：细菌外膜的哨兵
Biochim Biophys Acta. 2008 Sep;1778(9):1881-96. doi: 10.1016/j.bbamem.2007.07.021. Epub 2007 Aug 11.
4
PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium.PhoPQ介导的调控在鼠伤寒沙门氏菌的外膜中产生了更强的通透性屏障。
J Bacteriol. 2007 Oct;189(20):7213-22. doi: 10.1128/JB.00973-07. Epub 2007 Aug 10.
5
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6
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Mol Cell. 2007 Apr 27;26(2):165-74. doi: 10.1016/j.molcel.2007.03.008.
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Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor.通过一种保护响应调节因子不被其同源传感器去磷酸化的蛋白质来连接双组分调节系统。
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