Department of Population Health Research, Alberta Health Services, Calgary, Alberta, Canada.
Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2691-709. doi: 10.1158/1055-9965.EPI-10-0815. Epub 2010 Sep 10.
Sedentary behavior (prolonged sitting or reclining characterized by low energy expenditure) is associated with adverse cardiometabolic profiles and premature cardiovascular mortality. Less is known for cancer risk. The purpose of this review is to evaluate the research on sedentary behavior and cancer, to summarize possible biological pathways that may underlie these associations, and to propose an agenda for future research.
Articles pertaining to sedentary behavior and (a) cancer outcomes and (b) mechanisms that may underlie the associations between sedentary behavior and cancer were retrieved using Ovid and Web of Science databases.
The literature review identified 18 articles pertaining to sedentary behavior and cancer risk, or to sedentary behavior and health outcomes in cancer survivors. Ten of these studies found statistically significant, positive associations between sedentary behavior and cancer outcomes. Sedentary behavior was associated with increased colorectal, endometrial, ovarian, and prostate cancer risk; cancer mortality in women; and weight gain in colorectal cancer survivors. The review of the literature on sedentary behavior and biological pathways supported the hypothesized role of adiposity and metabolic dysfunction as mechanisms operant in the association between sedentary behavior and cancer.
Sedentary behavior is ubiquitous in contemporary society; its role in relation to cancer risk should be a research priority. Improving conceptualization and measurement of sedentary behavior is necessary to enhance validity of future work.
Reducing sedentary behavior may be a viable new cancer control strategy.
久坐行为（以低能量消耗为特征的长时间坐着或躺着）与不良的心血管代谢特征和过早的心血管死亡率有关。但对于癌症风险，我们知之甚少。本综述的目的是评估久坐行为与癌症的研究，总结可能潜在的生物学途径，并为未来的研究提出议程。
使用 Ovid 和 Web of Science 数据库检索与久坐行为和（a）癌症结局和（b）可能潜在的久坐行为与癌症关联的生物学机制相关的文章。
文献综述确定了 18 篇关于久坐行为与癌症风险或与癌症幸存者的久坐行为和健康结果相关的文章。其中 10 项研究发现久坐行为与癌症结局之间存在统计学上显著的正相关。久坐行为与结直肠癌、子宫内膜癌、卵巢癌和前列腺癌风险增加；女性癌症死亡率；以及结直肠癌幸存者的体重增加有关。关于久坐行为和生物学途径的文献综述支持肥胖和代谢功能障碍作为久坐行为与癌症之间关联的作用机制的假设。
久坐行为在当代社会中普遍存在；它与癌症风险的关系应成为研究重点。改善久坐行为的概念化和测量对于提高未来工作的有效性是必要的。
减少久坐行为可能是一种新的可行的癌症控制策略。
