Goulding P, Burjan A, Smith R, Lawson R, Snowden J, Northen B, Neary D, Testa H
Department of Neurology, Manchester Royal Infirmary, UK.
Eur J Nucl Med. 1990;17(1-2):77-82. doi: 10.1007/BF00819408.
A new semi-automatic method for quantifying regional cerebral uptake of 99m technetium-hexamethylpropylene amine oxime (99mTc-HMPAO) was used to assess single photon emission tomograms from 5 normal subjects, 14 patients with Alzheimer's disease, 14 patients with dementia of frontal lobe type and 4 patients with dementia with motor neurone disease. Uptake in both posterior cortical regions, although not in other regions, was significantly lower (P less than 0.05) in Alzheimer's disease than in normal controls. Conversely in both dementia of frontal lobe type and dementia with motor neurone disease, uptake was significantly reduced (P less than 0.05) compared with controls in all anterior cortical regions but not in posterior regions. Numerical findings in each disease mirrored the pattern of reduced tracer uptake previously reported by visual assessment. Nine patients were re-examined after an interval of at least 1 year. Comparison of follow-up scans with original images showed significant decreases in mid-anterior, left anterior and left posterior cortical uptake (P less than 0.01) in patients with Alzheimer's disease and in left middle, left posterior and right posterior cortical uptake (P less than 0.01) in patients with dementia of frontal lobe type. The method of quantification may be a useful adjunct to the visual assessment of single photon emission tomograms.
一种用于定量99m锝-六甲基丙烯胺肟（99mTc-HMPAO）脑区摄取的新型半自动方法，被用于评估5名正常受试者、14名阿尔茨海默病患者、14名额叶型痴呆患者以及4名合并运动神经元病的痴呆患者的单光子发射断层扫描图像。在阿尔茨海默病患者中，双侧后皮质区域的摄取量显著低于正常对照组（P<0.05），而其他区域则无此现象。相反，在额叶型痴呆和合并运动神经元病的痴呆患者中，与对照组相比，所有前皮质区域的摄取量均显著降低（P<0.05），而后皮质区域则无明显变化。每种疾病的数值结果都反映了先前通过视觉评估所报告的示踪剂摄取减少模式。9名患者在至少间隔1年后进行了复查。将随访扫描图像与原始图像进行比较发现，阿尔茨海默病患者的中前部、左前部和左后部皮质摄取量显著下降（P<0.01），额叶型痴呆患者的左中部、左后部和右后部皮质摄取量显著下降（P<0.01）。这种定量方法可能是单光子发射断层扫描视觉评估的一种有用辅助手段。
