General Basis of Surgery, Medical School, UNESP, Botucatu.
Braz J Otorhinolaryngol. 2010 Jul-Aug;76(4):478-84. doi: 10.1590/S1808-86942010000400012.
Hearing loss in hypothyroidism has been reported by many authors but its pathophysiology is unclear.
to study the audiological evaluation of patients with acquired hypothyroidism.
two groups were included: a hypothyroidism group (HG, n-30), and a control group (CG, n-30). Parameters studied: gender, time of hypothyroidism, comorbidities, cochleovestibular symptoms, biochemistry and hormonal exams (TSH, T4), tonal audiometry, TOAEs and BERA.
all participants were women, 70% of the HG had Hashimoto thyroiditis, 60% of the HG had had the diagnostic of the hypothyroidism for at least five years. Depression and hypertension were frequent in HG. All HG patients had altered TSH values and 50% had diminished T4 values. Sensorineural hearing loss was detected in 22 ears from the HG and in seven from the CG. BERA was normal in the CG and altered in 10 ears from the HG, showing L-V increase. TOAEs were absent in 12 ears from the HG and in four from the CG.
HG patients had more cochleovestibular symptoms, higher audiometric thresholds, increase in L-V in the BERA and absence or reduction in TOAEs amplitudes. Such alterations were not associated with THS and free T4 levels.
许多作者曾报道过甲状腺功能减退症引起的听力损失，但它的病理生理学机制尚不清楚。
研究获得性甲状腺功能减退症患者的听力学评估。
包括两组：甲状腺功能减退症组（HG，n=30）和对照组（CG，n=30）。研究参数：性别、甲状腺功能减退症时间、合并症、耳蜗前庭症状、生化和激素检查（TSH、T4）、纯音测听、耳声发射（TOAEs）和脑干听觉诱发电位（BERA）。
所有参与者均为女性，70%的 HG 患有桥本甲状腺炎，60%的 HG 至少有 5 年的甲状腺功能减退症诊断史。HG 中常见的合并症有抑郁和高血压。所有 HG 患者 TSH 值异常，50%的患者 T4 值降低。HG 中有 22 只耳朵检测到感音神经性听力损失，CG 中有 7 只耳朵检测到感音神经性听力损失。CG 的 BERA 正常，HG 的 10 只耳朵的 BERA 异常，表现为 L-V 增加。HG 中有 12 只耳朵的 TOAEs 缺失，CG 中有 4 只耳朵的 TOAEs 缺失。
HG 患者有更多的耳蜗前庭症状，更高的听力阈值，BERA 中的 L-V 增加，以及 TOAEs 幅度的缺失或降低。这些改变与 TSH 和游离 T4 水平无关。
