Faculdade de Medicina, Universidade de São Paulo, Instituto do Coração, Hospital das Clínicas, São Paulo, Brasil.
J Bras Pneumol. 2010 Jul-Aug;36(4):425-31. doi: 10.1590/s1806-37132010000400006.
To profile the characteristics of adult patients with bronchiectasis, drawing comparisons between cystic fibrosis (CF) patients and those with bronchiectasis from other causes in order to determine whether it is rational to extrapolate the bronchiectasis treatment given to CF patients to those with bronchiectasis from other causes.
A retrospective analysis of the medical charts of 87 patients diagnosed with bronchiectasis and under follow-up treatment at our outpatient clinic. Patients who had tuberculosis (current or previous) were excluded. We evaluated the clinical, functional, and treatment data of the patients.
Of the 87 patients with bronchiectasis, 38 (43.7%) had been diagnosed with CF, through determination of sweat sodium and chloride concentrations or through genetic analysis, whereas the disease was due to another etiology in 49 (56.3%), of whom 34 (39.0%) had been diagnosed with idiopathic bronchiectasis. The mean age at diagnosis was lower in the patients with CF than in those without (14.2 vs. 24.2 years; p < 0.05). The prevalence of symptoms (cough, expectoration, hemoptysis, and wheezing) was similar between the groups. Colonization by Pseudomonas aeruginosa or Staphylococcus aureus was more common in the CF patients (82.4 vs. 29.7% and 64.7 vs. 5.4%, respectively).
The causes and clinical manifestations of bronchiectasis are heterogeneous, and it is important to identify the differences. It is crucial that these differences be recognized so that new strategies for the management of patients with bronchiectasis can be developed.
分析成人支气管扩张症患者的特征，比较囊性纤维化（CF）患者和其他病因所致支气管扩张症患者，以确定将 CF 患者的支气管扩张症治疗方案外推至其他病因所致支气管扩张症患者是否合理。
回顾性分析在我院门诊接受随访治疗的 87 例支气管扩张症患者的病历。排除肺结核（现症或既往）患者。评估患者的临床、功能和治疗数据。
87 例支气管扩张症患者中，38 例（43.7%）通过汗液钠和氯浓度测定或基因分析诊断为 CF，而其他病因导致的支气管扩张症患者为 49 例（56.3%），其中 34 例（39.0%）诊断为特发性支气管扩张症。CF 患者的诊断年龄明显低于无 CF 患者（14.2 岁比 24.2 岁；p < 0.05）。两组患者的症状（咳嗽、咳痰、咯血和喘息）发生率相似。CF 患者铜绿假单胞菌或金黄色葡萄球菌定植更为常见（82.4%比 29.7%和 64.7%比 5.4%）。
支气管扩张症的病因和临床表现具有异质性，需要识别这些差异。认识到这些差异至关重要，以便为支气管扩张症患者制定新的管理策略。
