Zago Anderson Saranz, Kokubun Eduardo, Fenty-Stewart Nicola, Park Joon-Young, Attipoe Selasi, Hagberg James, Brown Michael
Escola de Educação Física e Esportes, USP, Ribeirão Preto, SP, Brasil.
Arq Bras Cardiol. 2010 Oct;95(4):510-6. doi: 10.1590/s0066-782x2010005000126. Epub 2010 Sep 17.
the T-786C polymorphism of the gene for endothelial nitric oxide synthase (eNOS) and superoxide anion production may reduce production and bioavailability of nitric oxide, affecting the degree of vasodilation. This effect can be reversed by exercise.
to investigate the influence of aerobic training and T-786C polymorphism in the concentrations of nitric oxide metabolites (NOx) in blood flow (BF) and blood pressure (BP).
thirty-two elderly pre-hypertensive women (59 ± 6 years old) were divided into two groups according to the T-786C polymorphism (TT and TC + CC). We analyzed the concentrations of NOx (plasma) and blood flow by venous occlusion plethysmography at rest, 1, 2 and 3 minutes post-occlusion (BF-0, BF-1 BF-2 BF-3, respectively). Evaluations were performed before and after 6 months of a program of aerobic exercise.
In the pre-training evaluations, NOx levels were lower in TC + CC group than in TT group. The TT group showed correlations between NOx and BF-0 (r = 0.6) and diastolic blood pressure (DBP) and BF-0 (r = -0.7), but no correlation was found in TC + CC group. In the post-training evaluations, there were correlations between NOx and BF-0 (r = 0.6) and the changes in NOx and DBP (r = -0.6) in TT group. There were also correlations between DBP and BF-1 (r = -0.8), DBP, and BF-2 (r = -0.6), DBP, and BF-3 (r = -0.6), in the changes between NOx and BF-1 (r = 0.8) and changes in NOx and DBP (r = -0.7) in TC + CC group.
it was concluded that 6 months of aerobic exercise can increase the relationship between NO, BP and BF in elderly of allele C carriers.
内皮型一氧化氮合酶（eNOS）基因的T-786C多态性与超氧阴离子生成可能会降低一氧化氮的生成和生物利用度，影响血管舒张程度。这种影响可通过运动逆转。
探讨有氧训练和T-786C多态性对血流（BF）和血压（BP）中一氧化氮代谢产物（NOx）浓度的影响。
32名老年高血压前期女性（59±6岁）根据T-786C多态性分为两组（TT和TC+CC）。我们通过静脉阻断体积描记法分析了静息时、阻断后1、2和3分钟时（分别为BF-0、BF-1、BF-2、BF-3）的NOx（血浆）浓度和血流量。在进行6个月的有氧运动计划前后进行评估。
在训练前评估中，TC+CC组的NOx水平低于TT组。TT组显示NOx与BF-0（r = 0.6）以及舒张压（DBP）与BF-0（r = -0.7）之间存在相关性，但在TC+CC组中未发现相关性。在训练后评估中，TT组中NOx与BF-0（r = 0.6）以及NOx变化与DBP（r = -0.6）之间存在相关性。在TC+CC组中，DBP与BF-1（r = -0.8）、DBP与BF-2（r = -0.6）、DBP与BF-3（r = -0.6）之间也存在相关性，NOx与BF-1变化（r = 0.8）以及NOx变化与DBP（r = -0.7）之间也存在相关性。
得出结论，6个月的有氧运动可增强老年C等位基因携带者体内NO、BP和BF之间的关系。
