Sorg H, Kuhbier J W, Menger B, Reimers K, Harder Y, Vogt P M
Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, Deutschland.
Chirurg. 2010 Nov;81(11):993-8. doi: 10.1007/s00104-010-1978-3.
Pleiotropic substances are characterized by their versatile and complex range of actions which makes them potential new active agents for the therapy of wounds. Besides its known effect to increase red blood cell production, the glycoprotein hormone erythropoietin (EPO) has been found to demonstrate a tissue protective effect in several other organs. The administration of EPO during skin wound healing is most likely essentially based on its cytopotective, proangiogenic, antiapoptotic and antiinflammatory effects. Herein EPO stimulates a coordinated interaction of different types of cells at a low or only a single dose. This review article aims to present the advantages and disadvantages of EPO administration in different experimental models to study the healing and regeneration processes of the skin and discusses possible clinical applications.
多效性物质的特点是其作用广泛且复杂，这使其成为伤口治疗潜在的新型活性剂。除了已知的增加红细胞生成的作用外，糖蛋白激素促红细胞生成素（EPO）已被发现在其他几个器官中具有组织保护作用。在皮肤伤口愈合过程中给予EPO很可能主要基于其细胞保护、促血管生成、抗凋亡和抗炎作用。在此，EPO以低剂量或仅单一剂量就能刺激不同类型细胞的协同相互作用。这篇综述文章旨在阐述在不同实验模型中给予EPO以研究皮肤愈合和再生过程的优缺点，并讨论其可能的临床应用。
