Department of Biology, University of Roma Tre, Italy.
Bull Environ Contam Toxicol. 2010 Oct;85(4):381-4. doi: 10.1007/s00128-010-0095-9. Epub 2010 Sep 11.
The aim of this study was to identify a new putative biomarker in Salmo trutta exposed to water pollution. Variations in the levels of hepatic 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMG-CoAR), the rate-limiting enzyme of cholesterol biosynthesis, were compared to heat shock protein 70 and hypoxia inducible factor α, biomarkers of pollution exposure and lowered O₂, respectively. The results confirm that HMG-CoAR levels increase in polluted water irrespective of water temperature or O₂ content, indicating that HMG-CoAR could be used as a specific biomarker for water pollution.
本研究旨在鉴定在受水污染暴露的鳟鱼中一种新的假定生物标志物。比较了肝脏 3-羟基-3-甲基戊二酰辅酶 A 还原酶（HMG-CoAR）——胆固醇生物合成的限速酶——的水平变化与热休克蛋白 70 和缺氧诱导因子 α 的水平变化，后者分别是污染暴露和降低的 O₂的生物标志物。结果证实，HMG-CoAR 水平在污染水中增加，而与水温或 O₂含量无关，表明 HMG-CoAR 可用作水污染的特异性生物标志物。
