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[氢化可的松对肝脏胆汁分泌功能的调节可能机制]

[Possible mechanism of regulation of the bile-secretory function of the liver by hydrocortisone].

作者信息

Masiuk A I, Dolgova E N

出版信息

Fiziol Zh (1978). 1990 Nov-Dec;36(6):46-51.

PMID:2083585
Abstract

Hydrocortisone has been studied for its effect on the bile secretion in rat under normal conditions and malfunction of hormonal induction mechanisms due to specific inhibitors of protein synthesis by actinomycin D, cycloheximide and puromycin. The character of changes in bile flow rate, observed as a response to hydrocortisone injection, depends on the intensity of transcription and translation processes in the rat liver cells.

摘要

已经研究了氢化可的松在正常条件下以及由于放线菌素D、环己酰亚胺和嘌呤霉素等蛋白质合成特异性抑制剂导致激素诱导机制功能失调时对大鼠胆汁分泌的影响。观察到的作为注射氢化可的松反应的胆汁流速变化特征取决于大鼠肝细胞中转录和翻译过程的强度。

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