Masiuk A I
Fiziol Zh Im I M Sechenova. 1993 Jun;79(6):147-53.
The enhanced bile secretion induced by hydrocortisone coincides in time with activation of the biosynthesis of intracellular and export proteins of the liver. Preliminary inhibition of the protein biosynthesis in the hepatocytes hinders the development of hypercholeretic effects of hydrocortisone or considerably distorts them. The activation of the protein biosynthesis in the liver cells is one of the main molecular mechanisms of choleretic action of glycocorticoids and a number of other hormones.
氢化可的松诱导的胆汁分泌增强与肝脏细胞内和输出蛋白生物合成的激活在时间上相吻合。预先抑制肝细胞中的蛋白质生物合成会阻碍氢化可的松利胆作用的发展或使其严重扭曲。肝细胞中蛋白质生物合成的激活是糖皮质激素和许多其他激素利胆作用的主要分子机制之一。
