Tiukhtin G M
Fiziol Zh (1978). 1990 Nov-Dec;36(6):90-3.
The value of the membrane potential of adrenocorticocytes (ACC) in zona fasciculata of isolated adrenal (IA) cortex and the activity of Na, K-ATPase of IA homogenate is determined in adult (6-7 months) and old (26-28 months) male Wistar rats. No significant age differences are found in the above indices. Administration of insulin in vivo (1.6 U/kg) and in vitro (0.1 U/ml) induced hyperpolarization of ACC plasmic membranes. Insulin increases the activity of Na, K-ATPase of IA in animals of both age groups. Ouabain and actinomycin D blocks the insulin-induced hyperpolarization of ACC, while 2-aminopyridine has no effect on this process. Insulin effect on the MP of IA ACC is less pronounced in old vs. adult animals.
在成年（6 - 7个月）和老年（26 - 28个月）雄性Wistar大鼠中，测定了分离肾上腺（IA）皮质束状带中肾上腺皮质细胞（ACC）的膜电位值以及IA匀浆中钠钾ATP酶的活性。在上述指标中未发现显著的年龄差异。体内（1.6 U/kg）和体外（0.1 U/ml）给予胰岛素可诱导ACC质膜超极化。胰岛素增加了两个年龄组动物IA中钠钾ATP酶的活性。哇巴因和放线菌素D可阻断胰岛素诱导的ACC超极化，而2 - 氨基吡啶对该过程无影响。与成年动物相比，胰岛素对老年动物IA中ACC膜电位的影响较小。
