Centre for Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Wiley Interdiscip Rev Syst Biol Med. 2009 Jul-Aug;1(1):45-60. doi: 10.1002/wsbm.27.
Bacterial quorum sensing (QS) has attracted much interest as the manifestation of collective behavior in prokaryotic organisms once considered strictly solitary. Significant amount of genetic, biochemical, and structural data which, has been accumulated in studies on QS in many species allows us to map properties of specific molecules and their interactions on the observed population-wide bacterial behavior. The present review attempts to give a systems biology perspective on the structure of genetic regulatory networks that control QS and considers functional implications of a variety of design principles that recur in the organization of these networks across species.
细菌群体感应（QS）作为原核生物集体行为的表现形式引起了广泛关注，这些原核生物曾被认为是严格的单细胞生物。在许多物种的 QS 研究中积累了大量的遗传、生化和结构数据，这些数据使我们能够在观察到的全种群细菌行为上绘制特定分子及其相互作用的特性图谱。本综述试图从系统生物学的角度来描述控制 QS 的遗传调控网络的结构，并考虑这些网络在物种间组织中反复出现的各种设计原则的功能意义。
