Division of Endocrinology, University of North Carolina, Chapel Hill, NC, USA.
J Bone Miner Res. 2010 Dec;25(12):2543-52. doi: 10.1002/jbmr.234.
Insulin-like growth factor-1 (IGF-1) plays a central role in cellular growth, differentiation, survival, and cell cycle progression. It is expressed early during development and its effects are mediated through binding to a tyrosine kinase receptor, the insulin-like growth factor-1 receptor (IGF-1R). In the circulation, the IGFs bind to IGF-binding proteins (IGFBPs), which determine their bioavailability and regulate the interaction between the IGFs and IGF-1R. Studies in animal models and in humans have established critical roles for IGFs in skeletal growth and development. In this review we present new and old findings from mouse models of the IGF system and discuss their clinical relevance to normal and pathological skeletal physiology.
胰岛素样生长因子-1(IGF-1)在细胞生长、分化、存活和细胞周期进展中发挥核心作用。它在发育早期表达,其作用通过与酪氨酸激酶受体胰岛素样生长因子-1 受体(IGF-1R)结合来介导。在循环中,IGFs 与 IGF 结合蛋白(IGFBPs)结合,这决定了它们的生物利用度并调节 IGFs 与 IGF-1R 之间的相互作用。动物模型和人类的研究确立了 IGFs 在骨骼生长和发育中的关键作用。在这篇综述中,我们呈现了 IGF 系统的小鼠模型的新发现和旧发现,并讨论了它们与正常和病理骨骼生理学的临床相关性。