Ferry R J, Katz L E, Grimberg A, Cohen P, Weinzimer S A
Department of Pediatrics, Children's Hospital of Philadelphia, Pennsylvania, USA.
Horm Metab Res. 1999 Feb-Mar;31(2-3):192-202. doi: 10.1055/s-2007-978719.
The insulin-like growth factors (IGFs), insulin-like growth factor binding proteins (IGFBPs), and the IGFBP proteases are involved in the regulation of somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogenic agents whose actions are determined by the availability of free IGFs to interact with the IGF receptors. IGFBPs comprise a family of proteins that bind IGFs with high affinity and specificity and thereby regulate IGF-dependent actions. IGFBPs have recently emerged as IGF-independent regulators of cell growth. Various IGFBP association proteins as well as cleavage of IGFBPs by specific proteases modulate levels of free IGFs and IGFBPs. The ubiquity and complexity of the IGF axis promise exciting discoveries and applications for the future.
胰岛素样生长因子（IGFs）、胰岛素样生长因子结合蛋白（IGFBPs）以及IGFBP蛋白酶在体内和体外均参与体细胞生长和细胞增殖的调控。IGFs是强效的促有丝分裂剂，其作用取决于游离IGFs与IGF受体相互作用的可利用性。IGFBPs是一类能以高亲和力和特异性结合IGFs的蛋白质家族，从而调节IGF依赖性作用。最近发现IGFBPs是不依赖IGF的细胞生长调节因子。多种IGFBP相关蛋白以及特定蛋白酶对IGFBPs的切割可调节游离IGFs和IGFBPs的水平。IGF轴的普遍性和复杂性预示着未来将有令人兴奋的发现和应用。
