Woods Amina S
Structural Biology Unit, Cellular Neurobiology Branch, NIDA IRP, NIH, Baltimore, MD 21224, USA.
J Recept Signal Transduct Res. 2010 Oct;30(5):331-6. doi: 10.3109/10799893.2010.513842.
The human D4 dopamine receptor is a synaptic neurotransmitter receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its structure makes it a very unusual and interesting G protein-coupled receptor (GPCR) as it has several polymorphic variants of its gene in the region encoding the third intracellular loop (IL3). This region contains from two to seven or more similar 48 base pair repeats. These repeats cause this protein to have a very high disorder index and this, in turn, makes it very interactive with other proteins. Among GPCRs in general, the unusually proline-rich IL3 is unique to the D4 receptor (D4R). We believe that, as in the D2R, this region of the receptor plays a role in it's interaction with other receptors.
人类D4多巴胺受体是一种突触神经递质受体，负责大脑中脑边缘系统的神经元信号传递，该脑区调节情绪和复杂行为。其结构使其成为一种非常特殊且有趣的G蛋白偶联受体（GPCR），因为在编码第三细胞内环（IL3）的区域，它有几个基因多态性变体。该区域包含两到七个或更多类似的48个碱基对的重复序列。这些重复序列导致该蛋白具有非常高的无序指数，进而使其与其他蛋白具有很强的相互作用。在一般的GPCR中，富含脯氨酸的异常IL3是D4受体（D4R）所特有的。我们认为，与D2R一样，该受体的这一区域在其与其他受体的相互作用中发挥作用。
