Antonucci Roberto, Bassareo Pierpaolo, Zaffanello Marco, Pusceddu Michele, Fanos Vassilios
Division of Neonatology and Pediatrics, Nostra Signora di Bonaria Hospital, San Gavino Monreale, Italy.
J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:34-7. doi: 10.3109/14767058.2010.509920.
Postnatal closure of the ductus arteriosus is crucial in the circulatory adaptation of the newborn to extrauterine life. In recent years, many studies have been performed to improve our understanding of both the physiology of the ductus arteriosus in the fetus and newborn, and the mechanisms underlying persistent ductal patency in the preterm infant. The pharmacological treatment of patent ductus arteriosus (PDA) remains a controversial issue. This article reviews the recent literature on the pathogenesis and clinical management of PDA in the preterm infant.
出生后动脉导管的关闭对于新生儿循环系统适应宫外生活至关重要。近年来，已经开展了许多研究，以增进我们对胎儿和新生儿动脉导管生理学以及早产儿动脉导管持续开放潜在机制的理解。动脉导管未闭（PDA）的药物治疗仍然是一个有争议的问题。本文综述了有关早产儿PDA发病机制和临床管理的最新文献。
