Neonatal Intensive Care Unit, Puericulture Institute And Neonatal Section, AOU University of Cagliari, Italy.
Clinics (Sao Paulo). 2011;66(12):2141-9. doi: 10.1590/s1807-59322011001200022.
Although the prophylactic administration of indomethacin in extremely low-birth weight infants reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage, it does not appear to provide any long-term benefit in terms of survival without neurosensory and cognitive outcomes. Considering the increased drug-induced reduction in renal, intestinal, and cerebral blood flow, the use of prophylaxis cannot be routinely recommended in preterm neonates. However, a better understanding of the genetic background of each infant may allow for individualized prophylaxis using NSAIDs and metabolomics.
虽然在极低出生体重儿中预防性使用吲哚美辛可以降低动脉导管未闭和严重脑室内出血的发生率，但在生存而没有神经感觉和认知结果方面似乎没有提供任何长期益处。考虑到药物诱导的肾、肠和脑血流减少增加，不能常规推荐在早产儿中使用预防。然而，对每个婴儿遗传背景的更好理解可能允许使用 NSAIDs 和代谢组学进行个体化预防。
