Max-Delbrück Center for Molecular Medicine, Berlin, Germany.
Semin Cell Dev Biol. 2010 Oct;21(8):855-63. doi: 10.1016/j.semcdb.2010.09.004. Epub 2010 Sep 15.
Canonical Wnt signaling supports the formation and maintenance of stem and cancer stem cells. Recent studies have elucidated epigenetic mechanisms that control pluripotency and stemness, and allow a first assessment how embryonic and tissue stem cells are generated and maintained, and how Wnt signaling might be involved. The core of this review highlights the roles of Wnt signaling in stem and cancer stem cells of tissues such as skin, intestine and mammary gland. Lastly, we refer to the characterization of novel and powerful inhibitors of canonical Wnt signaling and describe attempts to bring these compounds into preclinical and clinical studies.
经典 Wnt 信号通路支持干细胞和癌症干细胞的形成和维持。最近的研究阐明了控制多能性和干细胞特性的表观遗传机制，并首次评估了胚胎和组织干细胞是如何产生和维持的，以及 Wnt 信号通路可能是如何参与其中的。本文重点介绍了经典 Wnt 信号通路在皮肤、肠道和乳腺等组织的干细胞和癌症干细胞中的作用。最后，我们提到了新型有效经典 Wnt 信号通路抑制剂的特性，并描述了将这些化合物应用于临床前和临床研究的尝试。
